Abstract
We investigated the microbial production of 2-hydroxynicotinic acid (2-HNA) from nicotinic acid (NA) by intact cells of MCI3289, which was isolated from soil by enrichment culture with 6-methylnicotinic acid as the sole carbon source. The strain which showed the 2-HNA-producing activity was revealed to be a member of the β-subgroup of Proteobacteria. The 2-HNA-producing activity was induced by the addition of 6-methylnicotinic acid and 2-hydroxy-6-methylnicotinic acid to the culture medium. Intact cells of this strain incubated at 30°C in an optimal reaction mixture containing 15 g/l of NA produced 6.40 g/l of 2-HNA for 29 h.
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