Abstract
Dopamine-containing neurons in Parkinson's disease (PD) degenerate in different parts of substantia nigra (SN) to different degrees. The maximal neuron loss occurs in nigrosome-1, which is considered as a diagnostic biomarker in PD with iron-sensitive MRI techniques. However, clinical correlates of iron accumulation in nigrosome-1 remain unknown. Here, we measured quantitative susceptibility mapping (QSM) of nigrsome-1 using a 7 Tesla MRI and computed correlation with motor symptoms and with striatal dopamine terminal degeneration using 123I-ioflupane SPECT, to identify the clinical parameter that reflects nigrosome-1 degeneration.
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