Abstract
Mammary gland tumors are the most frequent neoplasm in dogs and are mostly malignant. Metastases ordinarily occur firstly at the pulmonary level, and subsequently in the lymph nodes, liver and kidneys. Less frequently, they appear at the bone. Therefore, the present study report a case of bone metastasis in a seven-year-old female boxer dog, consisting of poorly differentiated carcinoma that probably originated from mammary carcinoma. For the diagnosis, the bone biopsy was performed and the tissue fragmentsobtained were sent for histopathological examination. The positive immunohistochemical stain for cytokeratin 7 performed later reinforced the hypothesis that mammary carcinoma was the primary site of metastasis. The occurrences of bone metastases arising from the mammary gland are rare among dogs, possibly because metastasis is underdiagnosed and the animals do not reach the final stage of the disease. Thereby, there is a need to investigate the entire skeleton more accurately, in order to make an early diagnosis of bone metastasis and increase these animals’ survival.
Highlights
Tumors or neoplasms are abnormal tissue growths with accelerated development that involve alterations to cellular DNA and result in dysfunctions that control cell growth and differentiation (ANDRADE, 2008)
The present study report a case of bone metastasis in a female dog, comprising poorly differentiated carcinoma that probably originated from mammary carcinoma
The fragments showed malignant neoplasia profusely invading the bone tissue, characterized by papilliferous cordal outlines of cells with oval hyperpigmented nuclei, moderate pleomorphism, evident nucleoli, abundant cytoplasm with distinct borders and presence of numerous mitosis figures (Figure 2, 3 and 4). This was compatible with bone metastasis consisting of poorly differentiated carcinoma that probably originated from mammary carcinoma
Summary
Tumors or neoplasms are abnormal tissue growths with accelerated development that involve alterations to cellular DNA and result in dysfunctions that control cell growth and differentiation (ANDRADE, 2008) The prevalence of these neoplastic processes in dogs and cats. At the end of this period of time, the bone biopsy was performed and the tissue fragments obtained were sent for histopathological and microbiological examination. The fragments showed malignant neoplasia profusely invading the bone tissue, characterized by papilliferous cordal outlines of cells with oval hyperpigmented nuclei, moderate pleomorphism, evident nucleoli, abundant cytoplasm with distinct borders and presence of numerous mitosis figures (Figure 2, 3 and 4) This was compatible with bone metastasis consisting of poorly differentiated carcinoma that probably originated from mammary carcinoma.
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