Abstract
The present study investigated the effects of methylprednisolone on the vestibular compensation process following unilateral labyrinthectomy in guinea pigs. A single injection of methylprednisolone (15, 30 or 60 mg/kg s.c.), 15 min pre-labyrinthectomy, had no significant effect on either the severity or the rate of compensation of spontaneous ocular nystagmus or yaw head tilt; roll head tilt showed a significant change in the rate of compensation ( P < 0.005), due to increased roll head tilt in the 60 mg/kg group. However, a pre-labyrinthectomy injection of 30 mg/kg s.c. methylprednisolone followed by a second 30 mg/kg injection at 4 h post-labyrinthectomy resulted in a significant reduction in spontaneous nystagmus frequency ( P < 0.005) and a significant change in the rate of spontaneous nystagmus compensation ( P < 0.005). The additional 30 mg/kg injection had no significant effect on the magnitude or compensation of the postural symptoms. These results indicate that, at the optimal dose of 30 mg/kg, 2 injections of methylprednisolone (15 min pre-labyrinthectomy and 4 h post-labyrinthectomy) result in a significant reduction in spontaneous nystagmus frequency.
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