Methylphenidate but not Atomoxetine or Citalopram Increases Posterior/Anterior Default Mode Network Functional Connectivity

Abstract

Event Abstract Back to Event Methylphenidate but not Atomoxetine or Citalopram Increases Posterior/Anterior Default Mode Network Functional Connectivity M A Bellgrove1, F X Castellanos2, 3, R L Hester4, C. Kelly2*, M P Milham2 and L S Nandam1 1 The University of Queensland , Queensland Brain Institute and School of Psychology, Australia 2 NYU Child Study Center, Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, United States 3 Nathan Kline Institute for Psychiatric Research, United States 4 The University of Melbourne, School of Behavioural Science, Australia We previously showed that resting state functional connectivity (RSFC) between the anterior and posterior portions of the default mode network (DMN) was reduced in adults with ADHD, relative to controls (Castellanos et al., 2009). This RSFC decrement normalized with amphetamine treatment (Kelly et al., In submission), suggesting that connectivity within the DMN is subject to modulation by dopamine. To test this hypothesis and its dopaminergic specificity, we examined the effects of atomoxetine (60mg), methlyphenidate (30mg), and citalopram (30mg) on DMN RSFC in 24 healthy controls, using a randomized, placebo-controlled, cross-over design. One resting state EPI scan (198 volumes; TR=2000ms) was acquired under each drug condition. We computed and compared group-level RSFC of the posterior cingulate cortex (PCC) for each condition, controlling for nuisance signals. Whole-brain multiple comparisons correction was performed (Z>2.3; cluster significance: p<0.05). Methylphenidate significantly increased positive RSFC between PCC and medial prefrontal cortex (PFC), and increased negative RSFC between PCC and left ventrolateral PFC. These observations support the hypothesis that RSFC within the DMN is modulated by dopamine, and suggests that connectivity between the DMN and task positive networks is also affected by dopamine, which may explain behavioral improvements in healthy and clinical populations following methylphenidate treatment. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Neuropharmacology Citation: Bellgrove M, Castellanos F, Hester R, Kelly C, Milham M and Nandam L (2010). Methylphenidate but not Atomoxetine or Citalopram Increases Posterior/Anterior Default Mode Network Functional Connectivity. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00058 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Jun 2010; Published Online: 28 Jun 2010. * Correspondence: C. Kelly, NYU Child Study Center, Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, Newyork, United States, amclarekelly@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers M A Bellgrove F X Castellanos R L Hester C. Kelly M P Milham L S Nandam Google M A Bellgrove F X Castellanos R L Hester C. Kelly M P Milham L S Nandam Google Scholar M A Bellgrove F X Castellanos R L Hester C. Kelly M P Milham L S Nandam PubMed M A Bellgrove F X Castellanos R L Hester C. Kelly M P Milham L S Nandam Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.