Abstract
Deep vein thrombosis (DVT) is a common cause of morbidity and mortality, particularly in older people. Many genetic polymorphisms are considered as a risk factor of Hypercoagulability in DVT. MTHFR C677T polymorphism is reported to be associated with hyperhomocysteinemia through its inability to convert homocystein to methionnine which lead to hypercoagulable state that may promote DVT. The aim of this study was to examine the association of MTHFR (C677T) polymorphism with the risk of DVT in Sudan. The study included 50 DVT patients, their MTHFR C677T genotype frequencies (detected by PCR/RFLP) and haematological charecteristics (measured by Sysmex KX-21N) were determined and compared with 50 age and sex matched normal subjects as control. Low frequency of mutant MTHFR C677T genotype with 0% TT genotype (homozygote) and 12% CT (heterozygote) was observed. Our study showed a statistically insignifi
Highlights
Deep vein thrombosis or deep venous thrombosis (DVT) is the formation of a blood clot in a deep vein, predominantly in the legs[1]
methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is reported to be associated with hyperhomocysteinemia through its inability to convert homocystein to methionnine which lead to hypercoagulable state that may promote DVT[13]
We examined the association between MTHFR C677T polymorphism and the risk of DVT
Summary
Deep vein thrombosis or deep venous thrombosis (DVT) is the formation of a blood clot (thrombus) in a deep vein, predominantly in the legs[1]. It is a disease of aging, with a low rate of about 1 per 10,000 annually before the fourth decade of life, rising rapidly after age 45 years, and approaching 5–6 per 1000 annually by age 80[2]. DVT is the first and more common clinical form of venous thromboembolism (VTE). When endothelial injury occurs related to factors such as anoxia, mechanical stress, free radicals, cytokines, and thrombin, it may lead to platelet activation and coagulation [7]
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