Abstract
Posterior circulation vascular occlusive disease in children is a rare and uncommonly reported event. Among the numerous risk factors, the methylenetetrahydrofolate reductase (MTHFR) mutation is considered to be a common genetic cause of thrombosis in adults and children. Recently, a link between the MTHFR mutation and cerebrovascular disorders was reported in children. Diffusion tensor imaging (DTI) is a great improvement on magnetic resonance imaging (MRI), making the in vivo anatomical and pathological study of the brain and its fibers possible. In our patient cerebellar infarction was associated with MTHFR mutation and, in a standard neurological examination, DTI revealed normal white matter tracts.
Highlights
Our patient, a boy, was born at 36 weeks’ gestation by normal vaginal delivery and had Apgar scores of 9 and 10 after 1 and 5 minutes
Mutation and, in a standard neurological e examination, Diffusion tensor imaging u (DTI) revealed normal white matm ter tracts. om Introduction -c Posterior circulation vascular occlusive disn ease is rare in children whereas in adults underlying vascular disease accounts for a o high percentage of posterior circulation infarcN tion
The father was found to be homozygous for the methylenetetrahydrofolate reductase o (MTHFR) mutation and the mother was heterozygous for the MTHFR mutation
Summary
A boy, was born at 36 weeks’ gestation by normal vaginal delivery and had Apgar scores of 9 and 10 after 1 and 5 minutes. Over the few days drofolate reductase (MTHFR) mutation, which (dicoumarol), monitoring coagulation parame- the clinical condition of the boy improved is considered to be a common genetic cause of ters daily, and maintaining an INR index of markedly.
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