Abstract
We have synthesized cobalt ferrite nanoparticles (CFNPs), and evaluated them as agents for photothermal therapy. With a further coating of a layer of silica on the nanoparticles (SCNPs) using Stober process, the loading of a photosensitizer, methylene blue (MB), was achieved. The size and morphology of particles were characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), and dynamic light scattering (DLS). All these showed an increase in size from CFNPs to SCNPs, suggesting successful coating of silica. The formation of silica layer was confirmed using elemental analysis and Fourier transform infrared (FTIR) spectroscopy. The particles were ferromagnetic in nature, as obtained using vibrating sample magnetometry (VSM). The effective concentration of MB in particles, obtained using UV/Visible Spectroscopy, was 12 μM. The photo-induced hyperthermia experiment of CFNPs resulted in rise in temperature by eleven degrees. The use of the formulated particles in photodynamic therapy (PDT) was studied using singlet oxygen (1O2) photobleaching assay. This confirmed that particles generated 1O2 upon light irradiation, and its efficiency is comparable to that of free MB. Both the therapies combined together with magnetic targeting can give these particles potential to be used in localized cancer treatment.
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