Abstract

There is an ongoing interest of having a somatostatin analog radiotracer labeled with 18F for PET imaging of neuroendocrine tumors. Nonetheless, there is none yet approved for clinical use. 18F is the ideal radionuclide for PET imaging due to its high β+ decay, suitable half-life and ease of production. As with other peptides, the labeling of SSTA with 18F comes along with its complications. In this review, we discuss the methods to label SSTA with 18F highlighting the chemistry as well as an overview in the progress on preclinical and clinical applications of 18F-labeled SSTA tracers.

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