Abstract
Investigation of the brain pathology in experimental ischemia requires adequate methods for assessing the neurological deficit that occurs in laboratory animals, including sensory-based and behavioural disorders. In this research, we aimed to compare motor and behavioural disorders in rats with partial and subtotal experimental cerebral ischemia. The rats modelled with cerebral ischemia are found to exhibit a decrease in muscle strength, resistance to hypoxia, motor and emotional activity. The animals with incomplete cerebral ischemia demonstrated more pronounced sensory-based motor and behavioural disorders compared both with those modelled with partial cerebral ischemia and, in particular, with the control group.
Highlights
The expediency of studying the pathology of the brain in experimental ischemia necessitates adequate methods for assessing the neurological deficit that occurs in laboratory animals, including various sensory and behavioural disorders
A significant decrease in muscle strength was observed in both groups of the animals with cerebral ischemia (CI) compared to the control group
The rats after experimental CI have demonstrated a decrease in muscle strength, resistance to hypoxia, motor and emotional activity
Summary
The expediency of studying the pathology of the brain in experimental ischemia necessitates adequate methods for assessing the neurological deficit that occurs in laboratory animals, including various sensory and behavioural disorders. A number of methods can be used to study the degree of sensory-based motor and behavioural disorders in animals, such as the forced swimming, muscle strength, open field tests, as well as those for evaluating the modified indicators of the depth of a neurological deficit [3]. This article sets out to generalize the available literature data on contemporary approaches to assessing sensory-based motor reflexes, learning and memory abilities in experimental animals at different ages. In the early postnatal period, reflexes are assessed using such methods as the slip on the surface, negative geotaxis, avoidance of falling, reaction to acoustic stimuli, olfactory reaction and muscle strength tests. Sensory-based motor and behavioural disorders have been extensively studied using various models of cerebral ischemia (CI) [7,8,9,10]; the data obtained in these works has not far been properly generalized
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