Abstract
The purpose of the research described herein was to develop a new high performance liquid chromatography (HPLC) method for the assay of benzyl alcohol, ethylene glycol monophenyl ether, methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, and butyl hydroxybenzoate preservatives. The use of a reversed‐phase C18 column (250 mm×4.0 mm and 5 µm) using a gradient elution system enabled six compounds to be separated simultaneously in a single chromatographic run in less than 12 minutes. The method was successfully validated following ICH guidelines, and it has been demonstrated to be reliable for the assay of benzyl alcohol, ethylene glycol monophenyl ether, methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, and butyl hydroxybenzoate preservatives used in the manufacturing of drug products.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Liquid Chromatography & Related Technologies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
