Abstract
Two new disorazole analogues were synthesized by acid-promoted methanolysis of disorazole A1 (1). Structural elucidation of both products (2 and 3), through 1D and 2D NMR experiments, verified that each resulted from epoxide cleavage. With antiproliferative activities in susceptible cell lines comparable to that of disorazole A1, these methanolysis products indicate that the C-9-C-10 epoxide is not an essential structural component for biological activity.
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