Abstract
Methadone, a long-acting opioid agonist, binds to and occupies mu-opioid receptors, preventing withdrawal symptoms for 24 hours or longer, reduces craving for opioids, and, by maintaining high levels of opioid tolerance, reduces the euphoric effects of subsequent illicit opioid use.
Highlights
Methadone, a long-acting opioid agonist, binds to and occupies mu-opioid receptors, preventing withdrawal symptoms for 24 hours or longer, reduces craving for opioids, and, by maintaining high levels of opioid tolerance, reduces the euphoric effects of subsequent illicit opioid use
Concern regarding the proarrhythmic potential of methadone prompted a physician safety alert from the US Food and Drug Administration (FDA)
The ECG showed polymorphic ventricular tachycardia run with torsades de pointes which resolved spontaneously and an episode of loss of consciousness requiring a synchronized DC shock 150J; long QT 440ms
Summary
Received Date: November 03, 2014 Accepted Date: December 23, 2014 Published Date: December 27, 2014
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