Abstract
Study design: retrospective cohort study. Objectives: investigate clinical and pathological features, as well as the survival of metastatic breast cancer according to the site affected by the metastasis, osseous or extraosseous. Methods: the study population consisted of a cohort of 124 women with metastatic breast cancer assisted in an oncology referral hospital. The association between sociodemographic, tumoral and treatment variables and the site of metastasis was assessed with a chi-square test and the survival functions were estimated by the Kaplan-Meier method. Results: osseous-only metastasis was observed in 26.6% of patients and extra-osseous metastasis in 45.2%, the remainder presented metastasis in both sites. Among patients with osseous-only metastasis, 68.2% had been treated with hormonal therapy, compared with 44.9% of those with extraosseous metastasis (p=0.06); progesterone receptor–positive tumors were found in 63.6% and 43.3% of the patients in each group (osseous-only versus extraosseous), respectively (p=0.09). Overall 5-years survival rate was 38.5% (CI95%: 18.6-58.2) for patients with osseous-only metastasis and 24.8% (CI95%: 15.2-35.7) for patients with extraosseous metastasis. The mean survival time after the diagnosis of metastasis was 19.6 months in cases of bone-only metastasis and 12.1 in extraosseous metastasis. Conclusions: hormone receptor positivity and use of hormone therapy seem to be associated with the occurrence of isolated bone metastasis; patients within this group were suggested to have longer survival times.
Highlights
Tal seguimento foi realizado por meio do retorno aos registros médicos e complementado por busca no banco do Sistema de Informação sobre Mortalidade (SIM), contato telefônico, e, por fim, consulta no Cadastro de Pessoas Físicas (CPF) para obtenção do estado vital na condição de viva
Prognostic factors predicting survival from first recurrence in patients with metastatic breast cancer: analysis of 439 patients
Summary
Câncer de mama metastático: aspectos clinicopatológicos e sobrevida segundo o sítio de metástase. Objetivos: investigar aspectos clínicos, patológicos e sobrevida do câncer de mama metastático de acordo com o sítio acometido pela metástase, ósseo ou extraósseo. Metodologia: a população de estudo foi uma coorte de 124 mulheres com câncer de mama metastático atendidas em hospital de referência oncológica. Conclusões: a presença de positividade hormonal e o uso de hormonioterapia parecem estar associados a maior ocorrência de metástase óssea isolada, que, por sua vez, sinaliza para maior tempo de sobrevida em relação à metástase extraóssea. Faculdade de Medicina, Universidade Federal de Juiz de Fora (UFJF). Professora Titular da Faculdade de Medicina da Universidade Presidente Antonio Carlos (UNIPAC). Faculdade de Medicina, Departamento de Saúde Coletiva.
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