Abstract
Present-day science indicates that developing sensors with excellent sensitivity and selectivity for detecting early signs of diseases is highly desirable. Electrochemical sensors offer a method for detecting diseases that are simpler, faster, and more accurate than conventional laboratory analysis methods. Primarily, exploiting non-noble-metal nanomaterials with excellent conductivity and large surface area is still an area of active research due to its highly sensitive and selective catalysts for electrochemical detection in enzyme-free sensors. In this research, we successfully fabricate Metal-Organic Framework (MOF) FeBDC-derived Fe3O4 for non-enzymatic electrochemical detection of glucose. FeBDC synthesis was carried out using the solvothermal method. FeCl2.4H2O and Benzene-1,4-dicarboxylic acid (H2BDC) are used as precursors to form FeBDC. The materials were further characterized utilizing X-ray Powder Diffraction (XRD), Scanning Electron Microscopy (SEM), and Fourier-Transform Infrared Spectroscopy (FTIR). The resulting MOF yields good crystallinity and micro-rod like morphology. Electrochemical properties were tested using Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) with a 0.1 M of Phosphate Buffer Saline (PBS pH 7.4) solution as the supporting electrolyte. The measurement results show the reduction and oxidation peaks in the CV curve of FeBDC, as well as Fe3O4. Pyrolysis of FeBDC to Fe3O4 increases the peak of oxidation and reduction currents. The Fe3O4 sample obtained has a sensitivity of 4.67 µA mM−1.cm−2, a linear range between 0.0 to 9.0 mM, and a glucose detection limit of 15.70 µM.
Highlights
The dire need for rapid and reliable glucose monitoring has grown to be a developing concern over the past few years in food industries, biomedical, and clinical diagnostics
This challenge leads to numerous research and innovation that provide various methods for glucose detection, including fluorescent, optical, colorimetry, chromatographic, acoustic, and electrochemical [2,6,7,8,9,10]
Selectivity testing in this study aims to determine whether the sensor material can detect glucose using the Differential Pulse Voltammetry (DPV) measurement
Summary
The dire need for rapid and reliable glucose monitoring has grown to be a developing concern over the past few years in food industries, biomedical, and clinical diagnostics. The highest necessity is resulting from diabetes mellitus, a disease caused by abnormalities of blood sugar (glucose) level that impacts tens of millions of people everywhere in the world [1,2,3]. Insulin works by converting glucose or blood sugar into glycogen. It is essential to measure glucose levels in the body routinely to prevent the accumulation of glucose in the blood, which can cause diabetes [5]. This challenge leads to numerous research and innovation that provide various methods for glucose detection, including fluorescent, optical, colorimetry, chromatographic, acoustic, and electrochemical [2,6,7,8,9,10]. Among the methods mentioned above, the most cost-effective approach would be the electrochemical technique due to its excellent sensitivity, easy operational, simple instrumentation, and affordable cost [11,12,13,14]
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