Abstract
A novel and efficient C3-H vinylation reaction with quinoxalin-2(1H)-one as the substrate, in the presence of alkenes, under metal-free conditions, is reported herein. The reaction leads to the formation of new carbon–carbon bonds that exhibit moderate to good reactivities. The vinylation of quinoxalin-2(1H)-ones, in the presence of alkenes, is an attractive process that can be potentially utilized to produce biologically active 3-vinylated quinoxalin-2(1H)-ones.
Highlights
For Recent years have seen, the emergence of cross-dehydrocoupling (CDC) reaction, between two different molecules, as a prominent research topic (Girard et al, 2014; Huang et al, 2019; Mane et al, 2019; Liu et al, 2020; Xu et al, 2020)
The reaction condition was optimized with respect to bases to obtain better yields of the products (Table 1, entries 16–20)
After determining the optimal reaction conditions, we focused on expanding the scope of the reaction
Summary
For Recent years have seen, the emergence of cross-dehydrocoupling (CDC) reaction, between two different molecules, as a prominent research topic (Girard et al, 2014; Huang et al, 2019; Mane et al, 2019; Liu et al, 2020; Xu et al, 2020). When the reaction was carried out with 1-methylquinoxalin2(1H)-one 1a and styrene 2a as the-substrates, in the presence of PIFA (oxidant), in DMSO, the desired product was not obtained. The target compound was not obtained when the reaction was carried out in the absence of the oxidant (Table 1, entry 7).
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