Metabolism of the enantiomeric 1- O-alkyl glycerol ethers in the rat intestinal mucosa in vivo; incorporation into 1- O-alkyl and 1- O-alk-1′-enyl glycerol lipids

Abstract

1. 1. The incorporation of orally administered 1-O-(9,10-[ 3 H 2] octadecyl ) sn-glycerol and 3-O(1-[ 14 C] octadecyl ) sn-glycerol into alkyl acyl as well as alk-1′-enyl acyl glycerophosphoryl ethanolamine and alkyl diacyl glycerol of the rat intestinal mucosa was investigated in vivo. 2. 2. The enantiomers were found to be utilized to considerably different extents, the sn-1-isomer being the favored substrate in the above-mentioned biosynthetic reactions. 3. 3. The specific incorporation into alk-1′-enyl glycerol lipids of the 1- O-alkyl sn-glycerol as compared to the sn-3-isomer supports the view that the alk-1′-enyl glycerol bond is derived from the alkyl glycerol bond. 4. 4. The amount and chain length distribution of alkyl glycerol ethers naturally occurring in alkyl diacyl glycerols of the rat intestinal mucosa are reported.