Abstract
The metabolism of juvenile hormone I has been examined in rat hepatocyte suspensions. The hormone penetrates rapidly into the cells where its concentration becomes higher than in the incubation medium. About 25 per cent of the hormone is metabolized during min 1 of incubation, while at 30 min of incubation, essentially all the hormone has been metabolized into several organic-soluble and water-soluble metabolites. Eventually the organic-soluble metabolites (including the diol ester, the diol acid and the acid) are recycled by re-entry and are metabolized further into water-soluble metabolites. The most important water-soluble metabolite is the mercapturic acid followed by the glucuronide. These results suggest that the low toxicity of juvenile hormone in mammals may be explained, at least in part, by metabolic detoxication.
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