Abstract
The metabolism of bis-β-chloroethyl sulfide- 35S has been investigated in mice, rats and human subjects. In the rodents, the major portion of radioactivity was excreted in the urine within the first 24 hr, whereas in the human considerable radiosulfur was retained for long periods. In the rat only traces of radioactivity were expired, while small amounts were found in the feces. Large amounts of thiodiglycol and of bis-β-chloroethyl sulfone have been detected in the urine, largely as conjugates. Evidence is presented that much of the drug reacts immediately with glutathione, and this complex is excreted. It is concluded that the majority of the radioactivity excreted in the urine represents compounds formed from alkylation by the drug, rather than metabolites formed by enzymic action.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
