Abstract
Publisher Summary This chapter discusses the metabolic studies on ep mouse, a special strain with convulsive predisposition. An inbred strain of convulsive mouse was named “ ep mouse” because of the apparent similarities in convulsive seizures to those of human epileptic patients. Ep mouse did not respond to photic and/or acoustic stimulation. Seizure threshold in ep mouse in response to chemical stimulation was found lowered in comparison with that in nonconvulsive strains of mice. In ep mouse, 40 mg/kg of pentamethylenetetrazole was enough to produce generalized convulsions after intramuscular injection, while 60 and 70 mg/kg were required for nonconvulsive gpc and dd mice, respectively. In hybrid between the convulsive ep and nonconvulsive gpc mice, it was observed that the seesaw stimulation was effective in producing convulsions only after the 30th week after birth, in spite of stimulation given at one-week intervals from the fifth week onward. The increase in brain ammonia of ep mice with postural stimulation closely paralleled that of control mice that were chemically convulsed.
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