Abstract
BackgroundPolycystic ovary syndrome (PCOS) is characterized by reproductive disorder and increased risk of metabolic syndrome. This study aimed to assess the metabolic parameters in the cord blood of neonate of mothers with obese PCOS and comparison with non-obese PCOS and controls.MethodsThis retrospective cohort study was conducted in Arash and Kamali Hospital in 2017–2018. The biochemical test was conducted on 78 neonates from obese PCOS mothers, 78 neonates from non-obese PCOS mothers, and 78 neonates from healthy mothers. Finally, cord blood lipid profile and insulin and blood sugar were determined by specific kits. Correlations between variables were compared with chi-square, Mann-Whitney’s U, Kruskal-Wallis H tests and regression model by SPSS 23 and P < 0.05 was considered significant.ResultsTriglycerides (TG) and high-density lipoprotein cholesterol (HDL) were higher in cord blood of newborn of obese PCOS women than non-obese PCOS and controls (P = 0.02, P < 0.001, respectively). Also, the mean insulin was higher in cord blood of neonate of non-obese PCOS women than in obese PCOS and controls (12.26 ± 12.79 vs. 11.11 ± 16.51 vs. 6.21 ± 10.66, P = 0.01). But in the study, there was no significant difference between the mean of umbilical cord low-density lipoprotein cholesterol (LDL), total cholesterol and blood sugar in three groups. The logistic regression model showed that metabolic parameters were related to PCOS.ConclusionsIn the present study, there was a significant difference between the mean of umbilical cord HDL, cholesterol, and the insulin level in the three groups. But, there was no significant association between the mean of blood sugar, LDL, and TG in the groups. The metabolic disorder in PCOS might affect cord blood lipid and insulin and adulthood health.
Highlights
Polycystic ovary syndrome (PCOS) is characterized by reproductive disorder and increased risk of metabolic syndrome
Metabolic syndrome is associated with insulin resistance, hypertension, obesity, lower high-density lipoprotein cholesterol (HDL), higher low-density lipoprotein cholesterol (LDL), and increased fasting blood sugar (FBS) [5]
Metabolic syndrome and PCOS are both associated with increased rate of adverse neonatal and maternal pregnancy outcomes including gestational diabetes mellitus (GDM), hyperlipidemia, hypertension in mother, and maternal obesity and diabetes have been associated with macrosomia, risk for obesity, glucose intolerance and anderogen level disorder of the infant and the offspring [7]
Summary
Polycystic ovary syndrome (PCOS) is characterized by reproductive disorder and increased risk of metabolic syndrome. PCOS is associated with hormonal dysregulation such as hyperandrogenemia and disturbed gonadotropin secretion [2]. These result in chronic anovulation, and menstrual disorder obesity and insulin resistance, type II diabetes mellitus, dyslipidemia, hyperlipidemia, and cardiovascular disease [3]. Metabolic syndrome and PCOS are both associated with increased rate of adverse neonatal and maternal pregnancy outcomes including gestational diabetes mellitus (GDM), hyperlipidemia, hypertension in mother, and maternal obesity and diabetes have been associated with macrosomia, risk for obesity, glucose intolerance and anderogen level disorder of the infant and the offspring [7]
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