Abstract
A new metabolic pathway for felodipine was confirmed by identification and quantification of new felodipine metabolites retaining the dihydropyridine structure. Following administration of a 10mg dose to 6 healthy subjects, felodipine was rapidly absorbed, reaching maximum plasma concentration (Cmax) [22.5 ng/ml] after 1.5 hours, and was then eliminated with a half-life of 3.1 hours. The pyridine metabolite had a similar plasma concentration-time course to that of the parent compound, with a Cmax of 30.1 ng/ml and an elimination half-life of 2.8 hours. In contrast, the dihydropyridine metabolite (5-carboxy derivative) reached a Cmax value (47.8 ng/ml) 1.9 hours after administration and was eliminated with a half-life of 8.1 hours. This plasma dihydropyridine metabolite was identified by GC-MS (GC-mass spectrometry) in comparison with the standard material. The dihydropyridine metabolite was not detectable in urine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
