Abstract
Metabolic Disposition of Pyrithiones. Mitoma, C., Steeger, TM Rogers, J., Thomas, DM and Wedig, J.H. (1983). Fundam, Appl. ToxicoL 3: 256–263. The urinary pattern of pyri-thione metabolites in urine of the rat, rabbit and rhesus monkey was similar to that of the swine after iv. administration of sodium pyrithione (Sodium Omadine®) and the magnesium sulfateadduct of 2, 2′-dithio-bis(pyridine-l-oxide), (Omadine® MDS). The major metabolite accounting for 80% or more of the metabolites in urine was the S-glucuronide of 2-mercaptopyridine-N-oxide. After Omadine® MDS administration, three transient metabolites and one persistent metabolite were observed in the plasma. The transient metabolites were tentatively identified as 2-methylthiopyridine-N-oxide, 2-methylsulfinylpyridine and 2-methylsulfinyl-pyridine-N-oxide. 2-Methylsulfonylpyridine was the only metabolite observed in the plasma 16 hr after Omadine® administration. This metabolite could be detected 14 days after rats were treated repeatedly with a shampoo formulation containing Omadine MDS.
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