Abstract
The paper presents modern views on cardiovascular aspects of menopause and metabolic therapy of menopausal disturbances with meldonium (Mildronate®). The role of estrogen deficiency in climacteric disturbance development, key pathogenetic mechanisms of menopausal metabolic syndrome (MS), and relevant features of arterial hypertension and endothelial dysfunction development are discussed. The data on Mildronate® clinical use for cardiovascular prevention are summarized. The wide prevalence and multiple clinical manifestations of menopausal disturbances point to the need for their complex therapy. Mildronate® therapy is a new approach for systemic correction of metabolic disturbances in women with climacteric symptoms and menopausal MS.
Highlights
Представлен современный взгляд на сердечно-сосудистые аспекты менопаузы и возможности метаболической терапии мельдонием (Милдронатом®) менопаузальных нарушений
The wide prevalence and multiple clinical manifestations of menopausal disturbances point to the need for their complex therapy
Mildronate® therapy is a new approach for systemic correction of metabolic disturbances in women with climacteric symptoms and menopausal metabolic syndrome (MS)
Summary
Представлен современный взгляд на сердечно-сосудистые аспекты менопаузы и возможности метаболической терапии мельдонием (Милдронатом®) менопаузальных нарушений. Рассмотрена роль эстрогенного дефицита у женщин переходного периода в развитии климактерических нарушений, изложены основные механизмы развития менопаузального метаболического синдрома (МС), особенности формирования артериальной гипертонии, эндотелиальной дисфункции. Широкая распространенность и многообразие различных менопаузальных проявлений у женщин переходного периода диктует необходимость комплексной терапии этих нарушений.
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