Abstract
PURPOSE: Although the fructose-fed rat model exhibits many signals of the metabolic syndrome, the alterations observed are quite divergent among the studies. In search of an adequate animal model for the study of the effects of exercise on the development of the metabolic syndrome, the present study was designed to analyze metabolic characteristics of Wistar rats submitted to high fructose ingestion by different protocols. METHODS: In the first, two groups of adult rats (90 days old) were studied: a Control group (C 1; n = 6) received regular rodent chow and a Fructose group (F1; n= 6) was fed regular rodent chow and fructose was administered as a 10% solution in drinking water. In the second, also two groups of adult rats (90 days old) were evaluated: a Control group (C2; n = 6) was fed a balanced diet (AIN93) and a fructose group (F2; n= 6) was fed a purified 60% fructose diet. In the third, two groups of young rats (28 days old) were analyzed: a Control group (C3; n = 6) was fed the balanced AIN93 diet and a fructose diet group (F3; n= 6) was fed the 60 % fructose diet. The animals were evaluated with respect to: glucose tolerance (area under serum glucose concentrations during oral glucose tolerance test), peripheral insulin sensivity (serum glucose disappearance rates during subcutaneous insulin tolerance test), serum triglycerides concentration and mesenteric fat depot weight. C3 and F3 rats were also evaluated with respect to the aerobic capacity (maximal lactate steady state determination during swimming) RESULTS: Glucose tolerance was lower in the fructose groups F2 (10%) and F3 (10.4%) whereas serum triglycerides were higher (F2=99%, F3=60.2%) than in the respective controls (t- student P< 0.05). Insulin sensivity in F2 decreased (35.6%) and mesenteric fat depot weight increased (56.6%) in relation to C2. High fructose intake (F3) did not alter the aerobic capacity of the animals. CONCLUSIONS: In conclusion, high fructose intake is more effective in producing signals of metabolic syndrome in adult (90 days old) than in young (28 days old) Wistar rats. Also diet seems to be a more effective route for fructose administration than drinking water. Supported by Fapesp: process 07/54098-0; Capes and CNPq
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