Abstract
The role of mitochondrial dysfunction has recently emerged as a potential contributing factor in epilepsy. Acute seizures result in free-radical production, oxidative damage to cellular targets, impaired mitochondrial redox status, mitochondrial dysfunction, and apoptosis. A limited number of recent studies have also demonstrated mitochondrial dysfunction in chronic epilepsies. Importantly, mitochondrial dysfunction is a potential cause of epileptic seizures associated with disorders resulting from mutations of mitochondrial DNA. In this article, we review the emerging role of mitochondrial dysfunction in epilepsy.
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