Abstract
6 carcinogenic nitrosamines were studied in Salmonella typhimurium TA1535 after activation by S9 and by hypetocytes. All nitrosamines were activated by S9 from induced rats, regardless of their organotropy. The hepatocarcinogenic nitrosamines ( N-nitrosodimethylamine, NDEA; N-nitrosodiethylamine, NDEA; N-nitrosomorpholine, NM and N-nitrosodibutylamine, NDBA) were activated to mutagens by S9 and by hepatocytes both derived from noninduced rat livers, NDMA and NM inducing more his + revertants in the presence of hepatocytes. The oesophageal carcinogenic nitrosamine N-nitrosomethylbenzylamine (NMBeA) and bladder organotrophic N-nitroso(4-hydroxybutyl)butylamine (NBBOH) were neither converted by liver preparations of uninuced rats into mutagenic intermediates nor by hepatocytes. This study indicates that isolated class derived from untreated animals may be better suited to study liver specific activation in vitro that disrupted subceller metabolizing systems from induced animals.
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