Abstract
Research into the effects of breast cancer on delivery outcomes has generated inconsistent findings. To pool data from existing observational studies of the effect of breast cancer on preterm delivery and low delivery weight. A systematic literature search of PubMed, Embase, and Web of Science databases using keywords including, "breast cancer" and "birth outcome" up to March 7, 2017, was performed. Observational studies of the effect of breast cancer on delivery outcomes were included. Articles were reviewed independently by two authors and data were extracted. Risk ratios and 95% confidence intervals were calculated. Preterm delivery data were included from seven studies including 6687579 patients and low delivery weight data were retrieved from five studies including 6687103 patients. Maternal breast cancer was associated with an increased risk of preterm delivery (pooled risk ratio 1.82, 95% confidence interval 1.44-2.30) and low delivery weight (pooled risk ratio 1.41, 95% confidence interval 1.15-1.74). No publication bias was detected in the meta-analysis. The present meta-analysis demonstrated that maternal breast cancer was associated with increased risk of preterm delivery and low delivery weight.
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Schedule a callMore From: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
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