Abstract
BackgroundThe results showed that there was a certain correlation between the single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease, but there was no systematic study to verify this conclusion.AimsSystematic review of the association between single nucleotide polymorphism of IL-10-1082G/A locus and rheumatic heart disease.Materials and MethodsComputer retrieval PubMed, EMbase, Cochrane Library, CBM, CNKI, VIP and Data WanFang, the retrieval time limit from inception to June 2017. A case control study of single nucleotide polymorphisms and rheumatic heart disease in patients with rheumatic heart disease in the IL-10-1082G/A was collected. Two researchers independently screened the literature, extracted data and evaluated the risk of bias in the study, and using RevMan5.3 software for data analysis.ResultsA total of 3 case control studies were included, including 318 patients with rheumatic heart disease and 502 controls. Meta-analysis showed that there was no correlation between IL-10-1082G/A gene polymorphism and rheumatic heart disease [AA+AG VS GG: OR = 0.62, 95% CI (0.28, 1.39), P = 0.25; AA VS AG+GG: OR = 0.73, 95% CI (0.54, 1.00), P = 0.05; AA VS GG: OR = 0.70, 95% CI(0.47, 1.05), P = 0.08; AG VS GG: OR = 0.65, 95% CI (0.22, 1.92), P = 0.43; A VS G: OR = 0.87, 95% CI (0.71, 1.06), P = 0.17].ConclusionsWhen AA is a recessive gene, the single nucleotide polymorphism of IL-10-1082G/A is associated with the presence of rheumatic heart disease. Due to the limitations of the quantity and quality of the included literatures, the further research results were still needed.
Highlights
Rheumatic heart disease (RHD) is a class of autoimmune diseases caused by beta hemolytic group A induced by Streptococcus [1,2,3,4,5,6]
Meta-analysis showed that there was no correlation between Interleukin 10 (IL-10)-1082G/A gene polymorphism and rheumatic heart disease [AA+AG VS GG: or indirect ratio (OR) = 0.62, 95% CI (0.28, 1.39), P = 0.25; AA VS AG+GG: OR = 0.73, 95% CI (0.54, 1.00), P = 0.05; AA VS GG: OR = 0.70, 95% CI(0.47, 1.05), P = 0.08; AG VS GG: OR = 0.65, 95% CI (0.22, 1.92), P = 0.43; A VS G: OR = 0.87, 95% CI (0.71, 1.06), P = 0.17]
When AA is a recessive gene, the single nucleotide polymorphism of IL-10-1082G/A is associated with the presence of rheumatic heart disease
Summary
Rheumatic heart disease (RHD) is a class of autoimmune diseases caused by beta hemolytic group A induced by Streptococcus [1,2,3,4,5,6]. The results of the study show that the streptococcus antigens can simulate the human protein (especially in the heart of the protein) molecules, which lead to RHD patients have their own immune response [7,8,9]. Despite the continuous improvement of the modern medical environment, the RHD is still one of the important diseases causing human deaths in underdeveloped areas. The results showed that there was a certain correlation between the single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease, but there was no systematic study to verify this conclusion
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