Abstract
Objective To evaluate the performance of split-dosed polyethylene(PEG) for colonoscopy preparation. Methods Split-dose means that 1-3 L of PEG is taken in the afternoon or evening before examination and the remains in the next morning. And single-dose refers to all PEG is taken in the evening before examination. A meta-analysis was conducted to compare bowel preparation quality, adenoma detection rate and patients′ acceptance between groups. Results Ten randomized controlled trials were included into this study with 3 222 participants(1 481 in split-dose group and 1 741 in single-dose group). Split-dose group had higher rate of satisfactory bowel preparation(OR=3.37, 95%CI: 2.37-4.79), and so did the subgroup of 2~3 L PEG(OR=3.88, 95%CI: 2.39-6.29). Split-dose group did not improve adenoma detection rate significantly(OR=0.94, 95%CI: 0.71-1.24), but reported less adverse events such as nausea(OR=0.56, 95%CI: 0.42-0.74) and vomiting(OR=0.51, 95%CI: 0.30-0.88). Conclusion Split-dosed PEG provides better colon cleansing with higher patient compliance, but does not improve detection rate of adenoma. Key words: Adenoma; Colonoscopy; Adenoma detection rate; Bowel preparation; Polyethylene glycols
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
