Abstract
A recompilation of applications of mesoporous silica nanoparticles in sensing from the last five years is presented. Its high potential, especially as hybrid materials combined with organic or bio-molecules, is shown. Adding to the multiplying effect of loading high amounts of the transducer into the pores, the selectivity attained by the interaction of the analyte with the layer decorating the material is described. Examples of the different methodologies are presented.
Highlights
Since the 1990s, when mesoporous silica particles were published for the first time [5], many and very interesting applications were developed in different fields such as catalysis [6], energy applications [7,8] or nano-biomedicine, among others
Electrochemical sensors are already reviewed [15,16] and for this reason, in this review, we will focus on the use of mesoporous silica nanoparticles for the optical detection of different chemical species
The pores are loaded with a dye or fluorophore and capped with a molecule that acts as a molecular gate (Figure 2)
Summary
Since the 1990s, when mesoporous silica particles were published for the first time [5], many and very interesting applications were developed in different fields such as catalysis [6], energy applications [7,8] or nano-biomedicine, among others In the latter, they demonstrated satisfactory in-vitro performance, biocompatibility, non-toxicity and in-vivo bioavailability enhancement [9], and they were applied both in controlled drug release [10,11,12] and in diagnostics [13,14]. In the third approach, a more sophisticated procedure is used In this case, the pores are loaded with a dye or fluorophore and capped with a molecule that acts as a molecular gate (Figure 2). The pores are loaded with a dye or fluorophore and capped with a molecule that acts as a molecular gate (Figure 2) This molecular gate presents two different states: closed and open. The studied species are classified in the following groups: cations, anions, radicals, neutral analytes and miscellany
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