Abstract
Mesoporous materials with high specific surface, pores volume and unique pore size were recently intensively studied as bio-materials, such as carriers for controlled bio-active principles delivery. Mesoporous silica materials exhibit greater capacity for drugs loading and insure a controlled bio-active compound release if they are functionalized, in comparison with amorphous colloidal silica. Mesoporous silica nanomaterials have lately earned increasing interest also due to their substantial capability to be used in tumours treatment and imaging. Recently, functionalized mesoporous silica materials known a rapid development in imagistic and curative applications. This review summarizes the recent advancement in the obtaining and biological properties of mesoporous silica nanomaterials, emphasising the synthesis methods and drug delivery application. Commonly used synthetic strategies are discussed, followed by a systematic review of applicability in optical and MRI imaging.
Highlights
In 1906, Paul Ehrlich introduced the term “magic bullet,” referring to an antigen capability to specific select “side chains” on the cells surface (Strebhardt and Ullrich, 2008; Li et al, 2012)
The first surfactant-assisted synthesis of MCM-41 mesoporous silica (Mobil Composition of Matter No 41) was achieved by Mobil Company in 1992 (Kresge et al, 1992), but MCM-41 begun to be studied for bio-applications since 2001 as a matrix for drugs release (Vallet-Regi et al, 2001; Lin et al, 2012)
Afterwards, many investigations adopted the introduction of a co-solvent or another surfactant (Lin et al, 2012) for particles growth suppression, in order to get mesoporous silica nanomaterials with controlled size—Table 1 (Cai et al, 2001; Fowler et al, 2001; Lin and Tsai, 2003; Han and Ying, 2005; Berggren and Palmqvist, 2008; Sutewong et al, 2011)
Summary
In 1906, Paul Ehrlich introduced the term “magic bullet,” referring to an antigen capability to specific select “side chains” on the cells surface (Strebhardt and Ullrich, 2008; Li et al, 2012). The first surfactant-assisted synthesis of MCM-41 mesoporous silica (Mobil Composition of Matter No 41) was achieved by Mobil Company in 1992 (Kresge et al, 1992), but MCM-41 begun to be studied for bio-applications since 2001 as a matrix for drugs release (Vallet-Regi et al, 2001; Lin et al, 2012). First modified mesoporous silica nanomaterials for stimulireactive guided liberation of active compounds through chemically extractible nanoparticles as coatings were obtained in 2003 (Lai et al, 2003; Lin et al, 2012).
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