Abstract
Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm that accounts for less than 1% of all primary cutaneous neoplasms.1 A trabecular carcinoma was first described by Toker in 1972. It was named Merkel cell because it expresses Merkel cell markers, which are still being discussed. Regional incidences range from 0.1 to 0.88 / 100,000 person-years, but they are higher in countries like New Zealand and Australia.2 The majority of MCC cases (80%) are caused by Merkel Cell Polyomavirus (MCPyV) clonal integration into the host genome. In the remaining 20% of cases, UV mutations are responsible, and prolonged UV exposure is a factor.3,4 MCPyV early regions contain large and small T antigens, which have been shown to drive tumorigenesis. These proteins may play a role in MCC as well. Cells express a truncated form of LT protein that cannot replicate the virus but retains the domain that inhibits Retinoblastoma (Rb), the tumour suppressor.
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