Abstract
Dual probe porphyrin-gold nanorod polyelectrolyte microcapsules were developed to explore the enhancing effects of a plasmonic interface of self-assembled gold nanoparticles in the fluorescence emission from porphyrins loaded into the capsules’ core. An analysis of fluorescence lifetime imaging microscopy (FLIM) data reports a notable 105–106-fold increase in the maximum detected photon rates from diffraction-limited spots and an overall six-fold increase in fluorescence as averaged over the whole microcapsule area. Large emission enhancements were correlated with decreases in fluorescence lifetimes. The microcapsule’s design proved effective in achieving high fluorescent hybrids and may shed light on new possibilities for advanced materials imaging applications.
Highlights
IntroductionNanomaterials 2022, In recent years, polyelectrolyte microcapsules (PECs) have received a great deal of attention due to their possible use as drug delivery systems, biosensors, and microreactors [1,2]
InInsummary, compartmentalizedstructure structureofofpolyelectrolyte polyelectrolyte microcapsules can be used as efficient platforms to create spectrally engineered microsysmicrocapsules can be used as efficient platforms to create spectrally engineered tems for plasmonic fluorescence enhancement of weak emitters
To the best of our knowledge, this is the first example of polyelectrolyte microcapsules (PECs) emission events, which are 105 to 106-fold
Summary
Nanomaterials 2022, In recent years, polyelectrolyte microcapsules (PECs) have received a great deal of attention due to their possible use as drug delivery systems, biosensors, and microreactors [1,2]. Using the adequate polymers and number of assembled layers, fine control over a PEC’s structure can be achieved, allowing for devices with high biocompatibility and mechanical/chemical stability [1,3–5], which can load hydrophobic and hydrophilic molecules and promote their controlled and targeted release [6–8]. The integration of dyes, such as porphyrins, within these platforms enables the production of optically addressable devices and expands PECs’ use towards fields involving light. Porphyrins are important light-absorbing molecules that are largely recognized as photosensitizers for cancer photodynamic therapy and diagnosis due to their intrinsic ability to generate cytotoxic oxygen species and to emit in the red or near infrared when exposed to visible or UV light [9].
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