Abstract
BackgroundThere have been considerable studies on the effects of reproductive factors on thyroid cancer risk, while findings are inconsistent. In this analysis, we aimed to investigate the associations between menstrual, reproductive and hormonal factors with thyroid cancer occurrence in a population of Chinese women.MethodsUsing data from a 1:1 matched case–control study performed between 2015 and 2017 in Zhejiang Province of China, a second analysis of 2261 pairs of female subjects was conducted. The possible effects for thyroid cancer were evaluated in logistic regression models by odds ratios (ORs) with 95% confidence intervals (CIs).ResultsLater age at first pregnancy (for > 25 vs. ≦ 20 years, OR: 0.47, 95% CI 0.23–0.96) and longer duration of breast feeding (for 6–12 vs. ≦ 6 months, OR: 0.49, 95% CI 0.24–0.98) were significantly associated with decreased occurrence of thyroid cancer, while no trend was observed. Stratified by age at enrollment, only the association with duration of breast feeding remained significant, but limited to younger women (≦ 50 years).ConclusionsOur results suggested that women with later age at first pregnancy or longer breast feeding duration were less likely to have thyroid cancer. These findings supported an influence role of reproductive factors in thyroid cancer risk.
Highlights
There have been considerable studies on the effects of reproductive factors on thyroid cancer risk, while findings are inconsistent
Study subjects To explore the associations of diabetes mellitus and other factors with thyroid cancer, a 1:1 matched hospitalbased case–control study was performed in 7 counties (Lucheng, Pingyang, Cangnan, Cixi, Nanhu, Changxing and Yongkang) of Zhejiang Province
A total of 2937 pairs of subjects participated in the case–control study
Summary
There have been considerable studies on the effects of reproductive factors on thyroid cancer risk, while findings are inconsistent. In this analysis, we aimed to investigate the associations between menstrual, repro‐ ductive and hormonal factors with thyroid cancer occurrence in a population of Chinese women. Thyroid cancer is the most common cancer of the endocrine system [1] and the incidence has been increasing worldwide for the last decades [2]. In China, between 2000 and 2011, a dramatic rise in thyroid cancer incidence was observed among national female population, with an annual percentage change (APC) of 20.1% [3]. Epidemiological research has identified ionizing radiation and benign thyroid disease as established risk factors for thyroid cancer [9]. Previous studies showed that the female-to-male incidence ratio is found to be the largest during the years
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