Abstract

Subjects with alcohol use disorder (AUD) frequently present memory disorders affecting selective components of memory (episodic memory, working memory, semantic memory and procedural memory) even in absence of neurological complication. These mnemonic deficits are at least partially reversible with abstinence, but even after a few weeks of sobriety memory deficits can endure and potentially interfere with activities of daily life and therapeutic efforts. Establishment of the pattern and extent of memory deficits requires systematic testing. Most memory deficits occurring in AUD patients also occur to a greater extent in AUD patients with Korsakoff's syndrome, which is characterized by a severe and profound deficit in episodic memory (discussed in another article). These graded memory disorders from AUD to Korsakoff's syndrome therefore lend weight to a revival of the continuity theory, bridging symptoms from AUD, uncomplicated by medical syndromes such as liver or nutritional insufficiency, to AUD comorbid with such syndromes and attendant severe symptoms of amnesia.

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