Abstract
Plasma membranes in cells are asymmetric, an observation that dates 40 years. Recent observations suggest that these membranes present large lipid number asymmetries, with almost twice as many phospholipids on one of the leaflet than the other. Simulations provide an excellent avenue to probe behavior of these membranes. Here, I discuss the behavior of such membranes, in particular with respect to chemical asymmetries in the membrane. The work required to establish the phospholipid number asymmetry is also discussed, a quantity that is directly related to the work done on lipids by the so-called flippases and floppases proteins responsible for asymmetry homeostasis.
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