Abstract
The so-called membrane stabilizing effects of NCO-650 and its congeners were assessed on biomembranes (rat erythrocyte) and r.odel membranes (synthetic phospholipid vesicle). NCO-650 suppressed hypotonic hemolysis in biphasic manner. The maximum effect was observed at 40μM, whereas that of the next potent, 4-chlorophenyl trans-4-guanidinomethylcyclohexane carboxylate hydrochloride (GMCHA-4CP), was 200μM. NCO-650 depressed the transition temperature of dipalmitoylphosphatidylcholine unilamellar vesicle membranes between solid-gel and liquid-crystalline phases.
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