Abstract
Summary By using molecular dynamics simulations, we studied the behaviors of pure phos- pholipid membrane bilayer in an external electric field, which was applied perpen- dicular to the initial water/membrane interfaces. Results show that external electric fields can induce membrane reorientation and phase transition. The hydration level of lipid determines the final structure. When the hydration level is 71 water per lipid (w/l), it is a lamellar to lamellar reorientation. When the hydration level is 24 w/l, it is a lamellar to inverted cylinder phase transition. The water/membrane interfaces in different final structures are parallel to the direction of the external electric field. The results are consistent with the understanding on the universe behaviors of the dielectric interface in external electric fields. Electroporation is the initial step independent of the hydration level. Deformation, fusion, fracture and pore-resealing of membrane are observed during membrane reorientation and phase transition. Complex cubic phases with 3-dimensional connections for both membrane and water appear as the intermediate structures.
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