Abstract

Two novel Diels–Alder type adducts, melicodenines A ( 1) and B ( 2), were isolated from the leaves of Melicope denhamii (Seem.) T. G. Hartley and their structures were established by spectroscopic analyses, including extensive 2D NMR experiments. Compound 1 is a bisquinolinone alkaloid comprised of two N-methylflindersines ( 3), while compound 2 is the first naturally occurring quinolinone–acetophenone conjugate composed of 3 and an evodionol methyl ether ( 4).

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