Melatonin in menopausal metabolic syndrome formation.

Abstract

Women’s life has changed considerably during the last decades. Often it can be characterized by hypodynamia, high-energy, refined diet, disturbance of circadian rhythms (working in shifts, staying for a long time in front of the TV screen or computer). All these factors, as well as, hormonal changes, which are connected with reduction of women’s reproductive function, increase the risk of metabolic syndrome. Thus, search of new therapeutic agent is currently taking place. Such medicament should effect on all symptoms of metabolic syndrome, and at the same time should be well co-administered with other drugs. Probably, one of such drugs is melatonin. The literature search was held in Russian (elibrary, cyberleninka.ru) and international (pubmed, wiley online library) data bases for the last seven years. Free access to the full document was of top-priority. The choice was limited by two languages: Russian and English. The article contains information about the metabolic syndrome frequency in a population, and metabolic changes in women’s organism in post-menopause. The article focuses on the role of melatonin in the menopause metabolic syndrome formation. Mechanisms of the melatonin influence on all the metabolic syndrome components: obesity, arterial hypertension, blood lipids changes, and insulin resistance are studied. The correlation between the melatonin secretion decrease and the atherosclerosis and diabetes mellitus type II formation is observed. The article contains data about animal experiences and the melatonin use for its management in biological models. It is proved that melatonin has positive influence on metabolic syndrome symptoms in animal studies.