Abstract
Melanoma of unknown primary origin metastasizing to the ovary and breast: Case report and review of literature
Highlights
IntroductionCancers from outside female reproductive tract often metastasize to the ovary and account for less than 10% of all ovarian malignant neoplasms [1, 2]
We report a case of amelanotic malignant melanoma of unknown origin clinically manifesting as an ovarian mass
The absence of clinical history of melanoma made the diagnosis of this case very challenging
Summary
Cancers from outside female reproductive tract often metastasize to the ovary and account for less than 10% of all ovarian malignant neoplasms [1, 2]. Malignant melanoma (MM) is a tumor of high metastatic potential and frequently spreads to the skin, lymph nodes, lung, brain, liver and bone [4]. A 46-year-old multiparous Caucasian female presented with two weeks history of lower abdominal pain and increased abdominal girth Her medical history included viral hepatitis and alcohol abuse while her gynecological history was unremarkable. Frozen section showed the tumor was composed of solid sheets and nodules of malignant cells with numerous mitotic figures and apoptotic bodies. Sections from the left ovary, omental and peritoneal nodules showed tumor of the same morphology. Postoperative imaging showed the patient rapidly developed widespread metastatic disease to multiple organs including the brain, heart, liver, kidney, soft tissue, and lymph nodes. She had excellent response to the therapy with significant tumor regression, and was alive at six months follow up (BRAF inhibitors were reserved as second line therapy)
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