Abstract
Summary G2-arrested marine invertebrate oocytes are triggered to reenter the cell cycle by different extracellular signals (sperm, hormones and mimetics). They respond to competent signals either by germinal vesicle breakdown (for those arrested in prophase I) or by polar body emission (for those arrested in metaphase I or II). These cellular responses are easy to observe and quantify thus making of meiosis reinitiation an attractive model to study the transduction of signals endogenous to oocytes. Given the universal character of transmembrane coupling molecules and intracellular effectors, the specificity of cell and, in particular, oocyte response to an extracellular signal are mediated by the presence of specific receptors and by a specific set of intracellular effectors that are activated by them. In this paper we discuss the current limitations in molecular and pharmacological identification and characterization of invertebrate oocyte receptors. We next analyze signalling pathways triggered by activ...
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