Abstract
An 8-year-old girl who had a generalized seizure disorder from the age of 5 had an early onset of normal puberty and developed exacerbation of seizures and behavioral abnormalities during menstrual periods. The neurologic examination demonstrated only mild mental subnormality; a pneumoencephalogram showed slight ventricular dilatation. Oral medroxyprogesterone acetate (MPA) decreased seizure activity slightly. Subsequently following three biweekly injections of depot-MPA, the patient's menses ceased, and she became seizure-free for 4 months. There was associated improvement in behavior and school performance. Serum gonadotropin values remained normal, and no side effects were observed, except for increased appetite and weight gain.
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