Abstract
Balsalazide (BSZ) belongs to a class of non-steroidal anti-inflammatory drugs. Kinetics and mechanism of oxidation of BSZ with sodium N-halo-p-toluenesulfonamides viz., chloramine-T(CAT) and bromamine-T(BAT) in HClO4 medium have been spectrophotometrically investigated (\(\lambda _{\max } =\)357nm) at 303 K. Under comparable experimental conditions, reactions with both the oxidants follow a first-order dependence of rate on [BSZ] and fractional-order dependence on each [oxidant] and [HClO4]. Activation parameters and reaction constants have been computed. 2-hydroxy-5-nitroso-benzoic acid and 3-(4-nitroso-benzoylamino)-propionic acid are identified as the oxidation products of BSZ with both CAT and BAT. The rate of oxidation of BSZ is about five-fold faster with BAT than with CAT. Plausible mechanism and related rate law have been deduced for the observed kinetics. Kinetics of oxidation of balsalazide (BSZ) by chloramine-T and bromamine-T in HClO4 medium has been investigated. Both the reactions follow identical kinetics, with a first-order dependence of rate on [BSZ] and fractional-order dependence on each [oxidant] and [HClO4]. Plausible mechanism and related rate law have been deduced.
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