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Abstract
Melanoma is a malignant tumor with immunosuppression. Its immunosuppression is mostly due to myeloid-derived suppressor cells (MDSCs). At present, many studies have found that the generation of tumors is accompanied by the upregulation of certain factors and call them tumor markers. Some markers that cause tumor immunosuppression have been found in melanin. However, it is not clear how these markers work at the molecular level. The production of MDSCs, their migration into the tumor microenvironment (TME), their impact on T cells, and their unique function in the signal regulation pathway are all examined in this article. This study provides some references on pathways such as TLR4/NF-B, STAT3/Arg1 mRNA, such as STAT3/CCR5mRNA, etc. For the future research on the immunosuppression of melanoma. The pathways discovered so far are only a small part, and there are more pathways to be discovered. Future research can focus on the discovery of new pathways.
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