Abstract
The mechanisms of increasing the resistance of cells to significant temperature and damaging effects are typical, and cellular tolerance, ensuring the effectiveness of systemic regulation, is an important part of increasing the adaptive and rehabilitative potential of the entire organism. The expression of early genes encoding a wide range of stress-protective proteins increases the resistance of cells not only to significant temperature stimuli, but also to ischemia, hypoxia, and other damaging factors, forming the effects of cross-adaptation. Even a small change in temperature is significant enough to trigger the processes of genomic reprogramming. It seems to us important to consider the mechanisms of low-temperature therapeutic and rehabilitation technologies from the standpoint of cellular response to temperature stimuli. Currently, a large number of low temperature technologies (HT) are used in medical rehabilitation, which can be divided into two groups: moderately low temperature effects (from 30C to +20C) and extremely low temperature effects (from 30C to 180C), which includes the technology of extreme aerocriotherapy (EACT). The purpose of the review is to analyze the systemic and local mechanisms of EACT implemented with the participation of the main known stress-protective proteins.
Highlights
В медицинской реабилитации используют технологии воздействия, направленные на активацию собственных функциональных резервов адаптационных, компенсаторных или викарных возможн остей организма
The expression of early genes encoding a wide range of stress-protective proteins increases the resistance of cells to significant temperature stimuli, and to ischemia, hypoxia, and other damaging factors, forming the effects of cross-adaptation
A large number of low — temperature technologies (HT) are used in medical rehabilitation, which can be divided into two groups: moderately low temperature effects and extremely low temperature effects, which includes the technology of extreme aerocriotherapy (EACT)
Summary
В медицинской реабилитации используют технологии воздействия, направленные на активацию собственных функциональных резервов адаптационных, компенсаторных или викарных возможн остей организма. Системный ответ организма на действие низких или повышенных температур достаточно хорошо изучен, тогда как представления о роли клеточных реакций, развивающихся при вариациях температуры, начали формироваться в самое последнее время. Учитывая терминальные значения температуры при ЭАКТ, время воздействия обычно ограничивается 120–180 сек, а температура понижается только в поверхностных слоях кожи и субдермальных тканях.
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