Abstract
Abstract The present experiments were undertaken to determine the possible existence of a lymphocytosis-promoting factor in the plasmas of rats in which severe lymphocyte depletion was induced by the administration of rabbit, anti-rat lymphocyte sera (RARLS). Initial attempts to demonstrate the presence of such a factor were inconclusive. However, the possible presence of residual RARLS in the pooled donor plasmas necessitated the additional step of incubating the plasma with goat, anti-rabbit gamma globulin (GARGG) to remove the residual antiserum activity. Injections of this plasma into normal rats resulted in highly significant increases in their peripheral leukocyte numbers. This suggests that the depression of the leukocyte numbers produced by RARLS in the donor animals evoked the production of leukocytosis-inducing factors.
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