Abstract
Mechanisms of Aging in Bone Marrow Stem Cells
Highlights
Settling into middle-age typically brings the unpleasant realization that many things don’t work quite like they used to
Stuart Chambers, Margaret Goodell, and their colleagues investigated the molecular mechanisms underlying these deficits by using microarrays to analyze the gene expression profiles of aging hematopoietic stem cells (HSCs), the precursors of blood cells
The researchers found that genes involved in the inflammatory and stress response became more active with age, while genes important for regulating gene expression and genomic integrity became less active
Summary
Settling into middle-age typically brings the unpleasant realization that many things don’t work quite like they used to. New evidence suggests that this regenerative capacity declines with age as stem cells acquire functional defects.
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