Abstract
Summary. The causes of undemonstrable plasma fibrin‐stabilizing‐factor (FSF, factor XIII) activity in various diseases have been investigated. Results suggest impaired synthesis of the enzyme in three patients with portal cirrhosis, and one with acute hepatic necrosis. Impaired activation of factor XIII seems a possible explanation in one patient with portal cirrhosis. Evidence of a plasma inhibitor of factor XIII was obtained in six patients with chronic renal failure and two with acute hepatic necrosis. The inhibitor present in renal failure was non‐dialysable, relatively heat labile and not adsorbed by either aluminium hydroxide or bentonite.
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